Areas of Research

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Projects

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  Excellence network in mechanobiology (II). MINECO 2018-2019

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Publications

(*) Means equal contribution as senior authors.

2025

Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts.

Liceras-Boillos P, García-Navas R, Llorente-Gonzalez C, Lorenzo-Martín LF, Luna-Ramírez L, Fuentes-Mateos R, Calzada N, Vega FM, Holt MR, Ridley AJ, Bustelo XR, Vicente-Manzanares M, Santos E, Baltanás FC, 
Cell Commun Signal; 2025; 23(1); 116; 40033301

2023

Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.

Clavaín L, Fernández-Pisonero I, Movilla N, Lorenzo-Martín LF, Nieto B, Abad A, García-Navas R, Llorente-Gonzalez C, Sánchez-Martín M, Vicente-Manzanares M, Santos E, Alarcón B, Garcia-Aznar JM, Dosil M, Bustelo XR, 
Oncogene; 2023; 42(5); 389-405; 36476833

2022

Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells.

Ovejero-Sánchez M, Asensio-Juárez G, González M, Puebla P, Vicente-Manzanares M, Peláez R, González-Sarmiento R, Herrero AB, 
Int J Mol Sci; 2022; 23(21); 13019; 36361809

2021

The Crossroads between RAS and RHO Signaling Pathways in Cellular Transformation, Motility and Contraction.

Soriano O, Alcón-Pérez M, Vicente-Manzanares M, Castellano E, 
Genes (Basel); 2021; 12(6); 819; 34071831

2019

Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output.

Rodríguez-Fdez S, Citterio C, Lorenzo-Martín LF, Baltanás-Copado J, Llorente-Gonzalez C, Corbalán-García S, Vicente-Manzanares M, Bustelo XR, 
Cells; 2019; 8(12); E1649; 31888228

2017

Wavelet Imaging on Multiple Scales (WIMS) reveals focal adhesion distributions, dynamics and coupling between actomyosin bundle stability.

Toplak T, Palmieri B, Juanes-García A, Vicente-Manzanares M, Grant M, Wiseman PW, 
PLoS ONE; 2017; 12(10); e0186058; 29049414

Dasatinib Reversibly Disrupts Endothelial Vascular Integrity by Increasing Non-Muscle Myosin II Contractility in a ROCK-Dependent Manner.

Kreutzman A, Colom-Fernández B, Jiménez AM, Ilander M, Cuesta-Mateos C, Pérez-García Y, Arévalo CD, Brück O, Hakanen H, Saarela J, Ortega-Carrión A, de Rosendo A, Juanes-García A, Steegmann JL, Mustjoki S, Vicente-Manzanares M, Muñoz-Calleja C, 
Clin. Cancer Res.; 2017; 23(21); 6697-670; 28821556

Full L-regularized Traction Force Microscopy over whole cells.

Suñé-Auñón A, Jorge-Peñas A, Aguilar-Cuenca R, Vicente-Manzanares M, Van Oosterwyck H, Muñoz-Barrutia A, 
BMC Bioinformatics; 2017; 18(1); 365; 28797233

Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues.

Aguilar-Cuenca R, Llorente-Gonzalez C, Vicente C, Vicente-Manzanares M, 
F1000Res; 2017; 6(); 160; 28299195

2016

Erratum: CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.

Cibrian D, Saiz ML, de la Fuente H, Sánchez-Díaz R, Moreno-Gonzalo O, Jorge I, Ferrarini A, Vazquez J, Punzón C, Fresno M, Vicente-Manzanares M, Daudén E, Fernandez-Salguero PM, Martín P, Sánchez-Madrid F, 
Nat. Immunol.; 2016; 17(10); 1235; 27648548

CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.

Cibrian D, Saiz ML, de la Fuente H, Sánchez-Díaz R, Moreno-Gonzalo O, Jorge I, Ferrarini A, Vazquez J, Punzón C, Fresno M, Vicente-Manzanares M, Daudén E, Fernandez-Salguero PM, Martín P, Sánchez-Madrid F, 
Nat. Immunol.; 2016; 17(8); 985-96; 27376471

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.

Andradas C, Blasco-Benito S, Castillo-Lluva S, Dillenburg-Pilla P, Diez-Alarcia R, Juanes-García A, García-Taboada E, Hernando-Llorente R, Soriano J, Hamann S, Wenners A, Alkatout I, Klapper W, Rocken C, Bauer M, Arnold N, Quintanilla M, Megias D, Vicente-Manzanares M, Urigüen L, Gutkind JS, Guzmán M, Pérez-Gómez E, Sánchez C, 
Oncotarget; 2016; 7(30); 47565-47; 27340777

Concerning immune synapses: a spatiotemporal timeline.

Ortega-Carrión A, Vicente-Manzanares M, 
F1000Res; 2016; 5(); 10.12688; 27092248

Molecular control of non-muscle myosin II assembly.

Juanes-García A, Llorente-Gonzalez C, Vicente-Manzanares M, 
Oncotarget; 2016; 7(5); 5092-3; 26799185

2015

Free Form Deformation-Based Image Registration Improves Accuracy of Traction Force Microscopy.

Jorge-Peñas A, Izquierdo-Alvarez A, Aguilar-Cuenca R, Vicente-Manzanares M, Garcia-Aznar JM, Van Oosterwyck H, de-Juan-Pardo EM, Ortiz-de-Solorzano C, Muñoz-Barrutia A, 
PLoS ONE; 2015; 10(12); e0144184; 26641883

Fibroblast Migration in 3D is Controlled by Haptotaxis in a Non-muscle Myosin II-Dependent Manner.

Moreno-Arotzena O, Borau C, Movilla N, Vicente-Manzanares M, Garcia-Aznar JM, 
Ann Biomed Eng; 2015; 43(12); 3025-39; 26014363

A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front-back polarity.

Juanes-García A, Chapman JR, Aguilar-Cuenca R, Delgado-Arevalo C, Hodges J, Whitmore LA, Shabanowitz J, Hunt DF, Horwitz AR, Vicente-Manzanares M, 
J. Cell Biol.; 2015; 209(1); 23-32; 25869664

2014

Unleashing mesenchymal chemotaxis.

Aguilar-Cuenca R, Vicente-Manzanares M, 
Dev. Cell; 2014; 31(6); 669-70; 25535912

Myosin II in mechanotransduction: master and commander of cell migration, morphogenesis, and cancer.

Aguilar-Cuenca R, Juanes-García A, Vicente-Manzanares M, 
Cell. Mol. Life Sci.; 2014; 71(3); 479-92; 23934154

2013

Cell migration: cooperation between myosin II isoforms in durotaxis.

Vicente-Manzanares M, Vicente Manzanares M, 
Curr. Biol.; 2013; 23(1); R28-9; 23305668

2012

STICCS reveals matrix-dependent adhesion slipping and gripping in migrating cells.

Toplak T, Pandzic E, Chen L, Vicente-Manzanares M, Horwitz AR, Wiseman PW, 
Biophys. J.; 2012; 103(8); 1672-82; 23083710

The integrin-ligand interaction regulates adhesion and migration through a molecular clutch.

Chen L, Vicente-Manzanares M, Potvin-Trottier L, Wiseman PW, Horwitz AR, 
PLoS ONE; 2012; 7(7); e40202; 22792239

2011

Adhesion dynamics at a glance.

Vicente-Manzanares M, Horwitz AR, 
J. Cell. Sci.; 2011; 124(Pt 23); 3923-7; 22194302

Fungal lectin of Peltigera canina induces chemotropism of compatible Nostoc cells by constriction-relaxation pulses of cyanobiont cytoskeleton.

Díaz EM, Vicente-Manzanares M, Vicente C, Legaz ME, 
Plant Signal Behav; 2011; 6(10); 1525-36; 21897128

Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology.

Hodges JL, Newell-Litwa K, Asmussen H, Vicente-Manzanares M, Horwitz AR, 
PLoS ONE; 2011; 6(8); e24149; 21887379

High glucose-mediated oxidative stress impairs cell migration.

Lamers ML, Almeida ME, Vicente-Manzanares M, Horwitz AF, Santos MF, 
PLoS ONE; 2011; 6(8); e22865; 21826213

Cell migration: an overview.

Vicente-Manzanares M, Horwitz AR, 
Methods Mol. Biol.; 2011; 769(); 1-24; 21748665

Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells.

Vicente-Manzanares M, Newell-Litwa K, Bachir AI, Whitmore LA, Horwitz AR, 
J. Cell Biol.; 2011; 193(2); 381-96; 21482721

2010

Myosin light chain mono- and di-phosphorylation differentially regulate adhesion and polarity in migrating cells.

Vicente-Manzanares M, Horwitz AR, 
Biochem. Biophys. Res. Co; 2010; 402(3); 537-42; 20971064

2009

Dendritic Spines: Similarities with Protrusions and Adhesions in Migrating Cells.

Vicente-Manzanares M, Hodges J, Horwitz AR, 
Open Neurosci J; 2009; 3(); 87-96; 20559447

Non-muscle myosin II takes centre stage in cell adhesion and migration.

Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR, 
Nat. Rev. Mol. Cell Biol.; 2009; 10(11); 778-90; 19851336

Integrins in cell migration--the actin connection.

Vicente-Manzanares M, Choi CK, Horwitz AR, 
J. Cell. Sci.; 2009; 122(Pt 2); 199-206; 19118212

2008

Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner.

Choi CK, Vicente-Manzanares M, Zareno J, Whitmore LA, Mogilner A, Horwitz AR, 
Nat. Cell Biol.; 2008; 10(9); 1039-50; 19160484

Segregation and activation of myosin IIB creates a rear in migrating cells.

Vicente-Manzanares M, Koach MA, Whitmore L, Lamers ML, Horwitz AF, 
J. Cell Biol.; 2008; 183(3); 543-54; 18955554

2007

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase.

Owen KA, Pixley FJ, Thomas KS, Vicente-Manzanares M, Ray BJ, Horwitz AF, Parsons JT, Beggs HE, Stanley ER, Bouton AH, 
J. Cell Biol.; 2007; 179(6); 1275-87; 18070912

Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells.

Vicente-Manzanares M, Zareno J, Whitmore L, Choi CK, Horwitz AF, 
J. Cell Biol.; 2007; 176(5); 573-80; 17312025

2006

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.

Cabrero JR, Serrador JM, Barreiro O, Mittelbrunn M, Naranjo-Suárez S, Martín-Cófreces N, Vicente-Manzanares M, Mazitschek R, Bradner JE, Avila J, Valenzuela-Fernández A, Sánchez-Madrid F, 
Mol. Biol. Cell; 2006; 17(8); 3435-45; 16738306

Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics.

Nayal A, Webb DJ, Brown CM, Schaefer EM, Vicente-Manzanares M, Horwitz AR, 
J. Cell Biol.; 2006; 173(4); 587-9; 16717130

Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.

Martín-Cófreces NB, Sancho D, Fernández E, Vicente-Manzanares M, Gordón-Alonso M, Montoya MC, Michel F, Acuto O, Alarcón B, Sánchez-Madrid F, 
J. Immunol.; 2006; 176(7); 4201-7; 16547257

2005

Cell migration at a glance.

Vicente-Manzanares M, Webb DJ, Horwitz AR, 
J. Cell. Sci.; 2005; 118(Pt 21); 4917-9; 16254237

Synaptic clusters of MHC class II molecules induced on DCs by adhesion molecule-mediated initial T-cell scanning.

de la Fuente H, Mittelbrunn M, Sánchez-Martín L, Vicente-Manzanares M, Lamana A, Pardi R, Cabañas C, Sánchez-Madrid F, 
Mol. Biol. Cell; 2005; 16(7); 3314-22; 15872088

Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav.

Cruz-Adalia A, Vicente-Manzanares M, Martín-Cófreces NB, Cabrero JR, Dosil M, Alvarado-Sánchez B, Bustelo XR, Sánchez-Madrid F, 
Blood; 2005; 105(8); 3026-34; 15618472

2004

Role of the cytoskeleton during leukocyte responses.

Vicente-Manzanares M, Sánchez-Madrid F, 
Nat. Rev. Immunol.; 2004; 4(2); 110-22; 15040584

F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.

Caloca MJ, Zugaza JL, Vicente-Manzanares M, Sánchez-Madrid F, Bustelo XR, 
J. Biol. Chem.; 2004; 279(19); 20435-46; 14988412

Interactive protrusive structures during leukocyte adhesion and transendothelial migration.

Barreiro O, Vicente-Manzanares M, Urzainqui A, Yáñez-Mó M, Sánchez-Madrid F, 
Front. Biosci.; 2004; 9(); 1849-63; 14977592

Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1.

Sánchez-Martín L, Sánchez-Sánchez N, Gutiérrez-López MD, Rojo AI, Vicente-Manzanares M, Pérez-Alvarez MJ, Sánchez-Mateos P, Bustelo XR, Cuadrado A, Sánchez-Madrid F, Rodríguez-Fernández JL, Cabañas C, 
J. Biol. Chem.; 2004; 279(16); 16194-20; 14960575

Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells.

Gálvez BG, Matías-Román S, Yáñez-Mó M, Vicente-Manzanares M, Sánchez-Madrid F, Arroyo AG, 
Mol. Biol. Cell; 2004; 15(2); 678-87; 14657245

Measurement of the levels of polymerized actin (F-actin) in chemokine-stimulated lymphocytes and GFP-coupled cDNA transfected lymphoid cells by flow c

Vicente-Manzanares M, Vitón M, Sánchez-Madrid F, 
Methods Mol. Biol.; 2004; 239(); 53-68; 14573909

2003

The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes.

Vicente-Manzanares M, Rey M, Pérez-Martínez M, Yáñez-Mó M, Sancho D, Cabrero JR, Barreiro O, de la Fuente H, Itoh K, Sánchez-Madrid F, 
J. Immunol.; 2003; 171(2); 1023-34; 12847276

2002

Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes.

Rey M, Vicente-Manzanares M, Viedma F, Yáñez-Mó M, Urzainqui A, Barreiro O, Vazquez J, Sánchez-Madrid F, 
J. Immunol.; 2002; 169(10); 5410-4; 12421915

Cell adhesion and polarity during immune interactions.

Montoya MC, Sancho D, Vicente-Manzanares M, Sánchez-Madrid F, 
Immunol. Rev.; 2002; 186(); 68-82; 12234363

A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at

Serrador JM, Urzainqui A, Alonso-Lebrero JL, Cabrero JR, Montoya MC, Vicente-Manzanares M, Yáñez-Mó M, Sánchez-Madrid F, 
Eur. J. Immunol.; 2002; 32(6); 1560-6; 12115638

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

Barreiro O, Yanez-Mo M, Serrador JM, Montoya MC, Vicente-Manzanares M, Tejedor R, Furthmayr H, Sánchez-Madrid F, 
J. Cell Biol.; 2002; 157(7); 1233-45; 12082081

The leukocyte cytoskeleton in cell migration and immune interactions.

Vicente-Manzanares M, Sancho D, Yáñez-Mó M, Sánchez-Madrid F, 
Int. Rev. Cytol.; 2002; 216(); 233-89; 12049209

A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting.

Serrador JM, Vicente-Manzanares M, Calvo J, Barreiro O, Montoya MC, Schwartz-Albiez R, Furthmayr H, Lozano F, Sánchez-Madrid F, 
J. Biol. Chem.; 2002; 277(12); 10400-9; 11784723

A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular

Vicente-Manzanares M, Cabrero JR, Rey M, Pérez-Martínez M, Ursa A, Itoh K, Sánchez-Madrid F, 
J. Immunol.; 2002; 168(1); 400-10; 11751986

2001

Rho and Rho-associated kinase modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1.

Rodríguez-Fernández JL, Sánchez-Martín L, Rey M, Vicente-Manzanares M, Narumiya S, Teixidó J, Sánchez-Madrid F, Cabañas C, 
J. Biol. Chem.; 2001; 276(44); 40518-27; 11489881

2000

Cell polarization: a comparative cell biology and immunological view.

Vicente-Manzanares M, Sánchez-Madrid F, 
Dev. Immunol.; 2000; 7(2-4); 51-65; 11097201

Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner.

Borroto A, Gil D, Delgado P, Vicente-Manzanares M, Alcover A, Sánchez-Madrid F, Alarcón B, 
Eur. J. Immunol.; 2000; 30(12); 3403-10; 11093158

1999

Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes.

Del Pozo MA, Vicente-Manzanares M, Tejedor R, Serrador JM, Sánchez-Madrid F, 
Eur. J. Immunol.; 1999; 29(11); 3609-20; 10556816

Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.

Vicente-Manzanares M, Rey M, Jones DR, Sancho D, Mellado M, Rodriguez-Frade JM, Del Pozo MA, Yáñez-Mó M, de Ana AM, Martínez-A C, Mérida I, Sánchez-Madrid F, 
J. Immunol.; 1999; 163(7); 4001-12; 10491003

1998

The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes.

Vicente-Manzanares M, Montoya MC, Mellado M, Frade JM, Del Pozo MA, Nieto M, de Landazuri MO, Martínez-A C, Sánchez-Madrid F, 
Eur. J. Immunol.; 1998; 28(7); 2197-207; 9692889

Patents

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• Jenny Paola Alfaro García

  Jenny Paola Alfaro García

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• Olga Arjona Soriano

  Olga Arjona Soriano

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• Gloria Asensio Juárez

  Gloria Asensio Juárez

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• Judith Beni Ledesma

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• Mª del Rocío Bernal Zamorano

  Mª del Rocío Bernal Zamorano

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• Heidi Boas Martínez

  Heidi Boas Martínez

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• Irene Carta

  Irene Carta

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• Claudia Cifuentes Caballero

  Claudia Cifuentes Caballero

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• Víctor Coca Ruíz

  Víctor Coca Ruíz

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• Adam El-Kamis

  Adam El-Kamis

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• Marina Garrido Casado

  Marina Garrido Casado

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• María Gil Matos

  María Gil Matos

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• Clara Llorente González

  Clara Llorente González

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• Elisabetta Maffioli

  Elisabetta Maffioli

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• María Millán Salanova

  María Millán Salanova

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• Daniel Orive Mauleón

  Daniel Orive Mauleón

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• Rafael Pérez Díaz

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• Ernesto Pérez Sánchez

  Ernesto Pérez Sánchez

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• Clemence Thiant

  Clemence Thiant

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• Miguel Vicente Manzanares

  Miguel Vicente Manzanares

  Tumor biophysics

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  Miguel Vicente-Manzanares was born in Salamanca in 1973. He obtained his degree in Chemistry from the Universidad Complutense de Madrid, Spain, in 1996. He started his graduate studies in 1997 at the Universidad Autónoma de Madrid, Spain, under the scientific direction of Prof. Francisco Sánchez-Madrid. His Thesis work focused on the elucidation of signaling pathways that mediate cellular shape remodeling during chemotaxis. This work led to a PhD in 2002.

  Dr. Vicente-Manzanares moved to the U.S. in 2004 to work as a post-doc and then Research Scientist at the University of Virginia under the direction of Dr. Rick Horwitz. There, he identified mechanisms that control cellular polarity during cell migration, and the specific roles of non-muscle myosin II isoforms in a variety of cellular phenomena.

  In 2011, Dr. Vicente-Manzanares returned to Spain as an Assistant Professor of the Universidad Autónoma School of Medicine, Department of Medicine, and develops his research at the Instituto de Investigación Sanitaria-Princesa, in downtown Madrid.

  In 2017, he moved to Salamanca, Spain, to start the laboratory of tumor biophysics at the Instituto de Biologia Molecular y Celular del Cancer.

  Dr. Vicente-Manzanares has published more than 60 articles in top journals in the field of Cell Biology, including Nature Cell Biology, Journal of Cell Biology, Journal of Cell Science, etc., which have received over 7000 references.

  As an independent researcher, Dr. Vicente-Manzanares has been awarded three Plan Nacional research grants (2011, 2014, 2017), a Marie Curie Early Career Grant (2011) and two prestigious grants from the Fundación Ramón Areces (2012) and BBVA (2014).

  Prof. Vicente Manzanares is the coordinator of one subject of the Masters course in Biology and Clinical aspects of Cancer from the USAL: "CELL ADHESION AND MIGRATION IN CANCER", which deals with the cellular and molecular bases of metastasis, and participates in another subject: "ANTI-TUMOR IMMUNOTHERAPY".

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