CENTRO DE INVESTIGACION DEL CANCER

  • Laboratorio 17 CG

María del Carmen Guerrero Arroyo

C3G regulation of platelet function using animal models and its impact on ischemia and tumor metastasis


Biography

Our group is mainly interested in the study of the signaling mechanisms regulated by the C3G-Rap1 pathway in platelets that can contribute to different pathologies, such as the development of thrombotic diseases or cancer. For this, we have knockout and transgenic mouse models, in which the C3G gene is deleted or overexpressed, respectively, exclusively in megakaryocytes.

As a secondary line, we are also studying the role of C3G in hematopoiesis with an emphasis on megakaryopoiesis.

María del Carmen Guerrero Arroyo
Contact

Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n
37007 Salamanca
SPAIN

Areas of Research

Our group is mainly interested in the study of the signaling mechanisms regulated by the C3G-Rap1 pathway in platelets that can contribute to different pathologies, such as the development of thrombotic diseases or cancer. For this, we have knockout and transgenic mouse models, in which the C3G gene is deleted or overexpressed, respectively, exclusively in megakaryocytes.

As a secondary line, we are also studying the role of C3G in hematopoiesis with an emphasis on megakaryopoiesis.

Projects
  • Junta Castilla y León (2012-2000)

    Estudio del papel de c3G y P38 MAPK en la función plaquetaria y el desarrollo de los neutrófilos: implicaciones en la regulación del aleucemia mieloide crónica”

  • Junta de Castilla y León (2011-2013)

    Estudio del papel de c3G y P38 MAPK en la función plaquetaria y el desarrollo de los neutrófilos: implicaciones en la regulación del aleucemia mieloide crónica

  • MINISTERIO DE CIENCIA E INOVACIÓN (2011-2013)

    Papel de la ruta C3G-p3 8alfaMAPK en la patogénesis de la leucemia mieloide crónica utilizando modelos animales: Regulación de la adhesión celular y la función plaquetaria.

  • Junta de Castilla y León (2010-2011)

    Función de la ruta C3G-p38a mapk en la regulación de procesos de adhesión celular implicados en la patogénesis de la leucemia mieloide crónica: utilización de modelos animales

  • Instituto de Salud Carlos III (2008-2010)

    Mecanismos moleculares implicados en la regulación de la apoptosis y de la adhesión celular por la tura C3G/P38MAPK. Implicaciones en procesos tumorales.

  • Consejería de Educación. Junta de Castilla y León. SA078P20 (2006-2031)

    Role of C3G in hematopoietic tumors and platelet-mediated angiogenesis. Evaluation of its use as a therapeutic target.

    Consejería de Educación. Junta de Castilla y León. SA078P20

  • INSTITUTO DE SALUD CARLOS III (2005-2007)

    Caracterización del papel de la ruta C3G-P38MAPK sobre el balance supervivencia/muerte celular por apoptosis y transformación celular.

  • Instituto de Salud Carlos III (2003-2006)

    Actividad supresora de la transformación de C3G en la leucemia mieloide crónica.

  • (2001-2031)

    New functions for C3G in tumor progression, liver physiology and megakaryocyte and platelet biology. Contribution of platelet C3G to pathological neoangiogenesis and liver damage.

    Ministerio de Ciencia e Innovación. PID2019-104143RB-C21.

  • (0000-0000)

    Analysis in vitro and in vivo of C3G function in different cellular types and its impact in cardiovascular diseases and metastasis.

    Ministerio de Economía y Competitividad. SAF2013-48210-C2-1-R

  • (0000-0000)

    Role of C3G in the regulation of platelet function: Implications in angiogenesis and application to the prognosis and treatment of thrombotic diseases

    Consejería de Educación. Junta de Castilla y León. SA017U16

  • (0000-0000)

    Function of C3G in tumor development and liver pathophysiology. Implication of platelet C3G in angiogenesis and liver and cardiovascular disease.

    Ministerio de Economía y Competitividad. SAF2016-76588-C2-2-R.

Publications

(*) Means equal contribution as senior authors.



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Patents
Group
  • Mario Barrera Román Mario Barrera Román

    Mario Barrera Román

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    Email: mario.barrera@usal.es


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    Biography
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  • Pablo Berrocal Navarro Pablo Berrocal Navarro

    Pablo Berrocal Navarro

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    Email: pablo6bn@usal.es


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  • Cristina Fernández Infante Cristina Fernández Infante

    Cristina Fernández Infante

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    Email: crisferin@usal.es


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  • María del Carmen Guerrero Arroyo María del Carmen Guerrero Arroyo

    María del Carmen Guerrero Arroyo

    C3G regulation of platelet function using animal models and its impact on ischemia and tumor metastasis

    Telf.:

    Fax:

    Email: cguerrero@usal.es


    Contact

    Biography

    Our group is mainly interested in the study of the signaling mechanisms regulated by the C3G-Rap1 pathway in platelets that can contribute to different pathologies, such as the development of thrombotic diseases or cancer. For this, we have knockout and transgenic mouse models, in which the C3G gene is deleted or overexpressed, respectively, exclusively in megakaryocytes.

    As a secondary line, we are also studying the role of C3G in hematopoiesis with an emphasis on megakaryopoiesis.

    ×
  • Luis Hernández Cano Luis Hernández Cano

    Luis Hernández Cano

    Telf.:

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    Email: luishn220@gmail.com


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    Biography
    ×
  • Óscar Herranz Varea Óscar Herranz Varea

    Óscar Herranz Varea

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    Email: oherranz@usal.es


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    ×
  • Sandra Peral Yuste Sandra Peral Yuste

    Sandra Peral Yuste

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    Email: sandraperal@usal.es


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  • Natalia Soledad Sotelo Natalia Soledad Sotelo

    Natalia Soledad Sotelo

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    Email: nssotelo@usal.es


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  • Carlos Valdazo Martín Carlos Valdazo Martín

    Carlos Valdazo Martín

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    Email: carlosvaldazo@usal.es


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Formers Members