Biography
Role of Ras GEFs RasGrf1 and RasGrf2 in the Central Nervous System. Characterization of the proteins involved in physiological processes regulated by these GEFs: photoreception and memory generation.
Role for Ras Guanine Nucleotide Exchange Factors RasGrf1 and RasGrf2 in Central Nervous System
Role of Ras GEFs RasGrf1 and RasGrf2 in the Central Nervous System. Characterization of the proteins involved in physiological processes regulated by these GEFs: photoreception and memory generation.
Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n
37007 Salamanca
SPAIN
Fundación Solórzano (2012-2012)
Papel de los activadores de las oncoproteínas Ras:Sos y RasGrf en procesos fisiolçogicos y su relación con patologías humanas
MINISTERIO DE CIENCIA Y TECNOLOGÍA (2003-2005)
ANALISIS DE LA ESPECIFICIDAD FUNCIONAL DEE LOS INTERCAMBIADORES DE NUCLEOTIDOS DE GUANINA PARA RAS, GRF1 Y GRF2
(*) Means equal contribution as senior authors.
Alberto Antolín Lerma
Noelia Bautista Estévez
Nuria Calzada Nieto
María Carranza Jiménez
María Carranza Jiménez
Juan Carlos Fernández Izquierdo
Alberto Fernández Medarde
Role for Ras Guanine Nucleotide Exchange Factors RasGrf1 and RasGrf2 in Central Nervous System
Telf.:
Fax:
Email: afm@usal.es
Role of Ras GEFs RasGrf1 and RasGrf2 in the Central Nervous System. Characterization of the proteins involved in physiological processes regulated by these GEFs: photoreception and memory generation.
× Rocío Fuentes Mateos
Characterization of the phenotypical alterations in H-Ras & N-Ras double KO mice
Telf.:
Fax:
Email: rocfuemat@gmail.com
RÓSULA GARCÍA NAVAS
Carmela Gómez Rodríguez
María Santos Jiménez Rodríguez
Mª Pilar Liceras Boillos
Marta López Yus
Cynthia Mucientes Valdivieso
Andrea Olarte San Juan
Ophélie Poveda
Valerio Ramos Bravo
Pablo Rodríguez Ramos
Eugenio Santos de Dios
RAS GENE PRODUCTS IN PROLIFERATION AND DIFFERENTIATION SIGNALING PATHWAYS
Telf.: +34 923 294 801
Fax:
Email: esantos@usal.es
Dr. Eugenio Santos de Dios
Investigador Principal y director del Centro de Investigación del Cáncer
Laboratorio Nº 1.
Catedrático, Departamento de Microbiología y Genética de la Universidad de Salamanca.
923 294 720 (Ext. 4773)
923 294 743
cicancer(arroba)usal(.)es
Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n
37007 Salamanca
SPAIN
Dr. Santos received his Ph.D. from the Department of Microbiology, University of Salamanca, in 1978. He carried out postdoctoral training at the Roche Institute of Molecular Biology (Nutley, NJ) (79-81) and the Laboratory of Cellular and Molecular Biology of the National Cancer Institute (NIH, Bethesda, MD) (81-84), where he later remained as a Principal Investigator until 2000, when he rejoined the University of Salamanca as Full Professor of Microbiology and Director of the Cancer Research Institute (USAL-CSIC).
Dr Santos’s scientific career has evolved closely in step with the field of molecular oncology. As a young postdoc at NCI in the early 1980s he cloned and characterized the first human oncogene (H-ras, from T24 bladder carcinoma cells). Following those seminal contributions that inaugurated the field of human oncogenes, his research has always focused on analysing the structure, function and regulation of the Ras family of genes and proteins. In the 1980s Santos completed the pioneering work of isolating the H-ras oncogene and demonstrating its oncogenic activation by point mutation, by demonstrating, for the first time in humans, the presence of an activated K-ras oncogene in the tumoural tissue – and its absence in the normal tissue – of the same patient. In the 1990s Dr Santos’s laboratory used Ras-dependent proliferation or differentiation models, such as Xenopus oocytes or 3T3L1 pre-adipocytes, to achieve further progress in understanding the structure and function of Ras proteins and their involvement in signal transduction pathways that control cell proliferation and differentiation in eukaryotes. Finally, from 2000 onwards, Santos’s research has demonstrated the functional specificity of the canonical members of the Ras family (H-ras, N-ras and K-ras) and their specific cellular activators (GEF, guanine nucleotide exchange factors) of the GRF and SOS families, using an experimental approach that involves the genomic and proteomic characterization of knockout mouse strains for several Ras and GEF genes.
Dr Santos is Spain’s national coordinator of the Spanish Cooperative Cancer Research Network (RTICC, sponsored by the Carlos III Health Institute). He sits on several editorial and scientific advisory boards, and has supervised more than fifty postdoctoral and postgraduate researchers throughout his scientific career. Santos is the recipient of several scientific awards, including the Severo Ochoa Award for Biomedical Research (1996) and the Echevarne Oncology Award (2010). He is a member of the Royal Academy of Medicine (RAMSA, Salamanca, Spain, 2003) and of the European Academy of Cancer Sciences (EACS, Brussels, 2011).
× Belén Zamora Valdivieso
Nuria Ajenjo Díez
BEGOÑA ANTA RODRÍGUEZ
ximena Marcela Bonilla Fore
Fernando Calvo Baltanás
Jaime Font de Mora Saínz
Rocio Fuentes Mateos
Characterization of the phenotypical alterations in H-Ras & N-Ras double KO mice
Telf.:
Fax:
Email: rocfuemat@usal.es
Alicia Ginel Picardo
Javier Gutiérrez Berzal
Lara Mañes Font
Alejandro Núñez Alonso
María Sanz Vicente
Alicia Solórzano Quijano