CENTRO DE INVESTIGACION DEL CANCER

  • Laboratorio 15

Azucena Esparís Ogando

Mek5/ERK5 pathway in cancer. Therapies directed against ERK5.


Biography
Azucena Esparís Ogando
Contact

Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n

teléfono 923 294815

           

37007 Salamanca SPAIN

Areas of Research

1. Mek5/ERK5 pathway in cancer

(i) We are analyzing the tumorigenic capacity of ERK5 in the breast by generating an animal model of expression of MEK5DD (the constitutively active form of MEK5) in the breast epithelia.

(ii) We intend to identify genes regulated by either gain or loss-offunction of ERK5, by using several cellular models.

(iii) We are investigating the participation of ERK5 in the proliferation of triple negative breast cancer cells, as we have also observed increased levels of ERK5 in this subtype of breast cancer.

2. Therapies directed against ERK5

Because ERK5 pathway could represent a new therapeutic target, we aim to:

(i) study the efficiency, in breast cancer, of an inhibitor directed against ERK5, designed by an US-based company

(ii) identify proteins that are associated with ERK5.

Projects
  • Instituto de Salud Carlos III (2016-2018)

    La ruta de MEK5/ERK5 como diana terapéutica en cáncer

  • Junta de Castilla y León (2010-2010)

    Identificación de nuevos componenetes de lavía de Erk5, y terapias dirigidas contra esta quinasa

  • Fundación Samuel Solórzano Barruso (2010-2010)

    La ruta de MEK5/Erk5 en cáncer

  • Instituto de Salud Carlos III (2010-2013)

    La ruta de ERK5 en cáncer

  • Junta de Castilla y León (2008-2008)

    “Quinasas en cáncer de mama con fenotipo basal”

  • Instituto de Salud Carlos III (2007-2009)

    LA RUTA DE MEK5/ERK5 EN CANCER DE MAMA

  • Junta de Castilla y Leon (2006-2008)

    La ruta de MEK5/ERK5 en cáncer de mama

  • Junta de Castilla y León (2006-2006)

    La vía de transducción de señales ERK5 en pacientes con cáncer de mama

  • INSTITUTO DE SALUD DE CARLOS III (2005-2008)

    Neuregulinas, receptores ERBB, y señalización por ERK5 en cáncer

NCBI-PubMed Articles
Publications

(*) Means equal contribution as senior authors.



2024
2023
2020
2019

MEK5 promotes lung adenocarcinoma.

Sánchez-Fdez A, Ortiz-Ruiz MJ, Re-Louhau MF, Ramos I, Blanco-Múñez Ó, Ludeña D, Abad M, Sánchez-Martín M, Pandiella A, Esparís-Ogando A, 
Eur Respir J; 2019; 53(2); 1801327; 30442718


2017
2016
2015
2014
2013
2009
2008

Neuregulins and cancer.

Montero JC, Rodríguez-Barrueco R, Ocaña A, Díaz-Rodríguez E, Esparís-Ogando A, Pandiella A, 
Clin. Cancer Res.; 2008; 14(11); 3237-41; 18519747


2007
2005

Multifunctional role of Erk5 in multiple myeloma.

Carvajal-Vergara X, Tabera S, Montero JC, Esparís-Ogando A, López-Pérez R, Mateo G, Gutiérrez N, Parmo-Cabañas M, Teixidó J, San Miguel JF, Pandiella A, 
Blood; 2005; 105(11); 4492-9; 15692064


2002
2000
1999
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  • Azucena Esparís Ogando Azucena Esparís Ogando

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    Mek5/ERK5 pathway in cancer. Therapies directed against ERK5.

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    Dr. Atanasio Pandiella
    Investigador científico del CSIC
    Laboratorio Nº 15

    923 294 815
    923 294 743
    atanasio(arroba)usal(.)es

    Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
    Campus Universitario Miguel de Unamuno s/n
    37007 Salamanca
    SPAIN


    Biography

    Dr. Pandiella obtained his Ph.D degree in Medicine and Surgery from the University of Santiago de Compostela in 1987. His scientific training outside Spain includes four years (1985-1989) as a pre- and post-doctoral student at the Ospedale San Raffaele in Milan and three years at the Memorial Sloan Kettering Cancer Center (1989-1992 New York, U.S.A)
    Later, for one year, Dr. Pandiella worked at the Department of Physiology of the University of Las Palmas in the Canary Islands. From 1994 up to 2001, he has been on the team of the Institute of Biochemical Microbiology of the University of Salamanca. His research line focuses on the functional characterisation of molecules involved in the genesis and promotion of different solid tumours in humans, in particular breast cancers.

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