CENTRO DE INVESTIGACION DEL CANCER

  • Laboratorio 2

Mercedes Dosil Castro

Ribosome synthesis and cell growth

Biography

Mercedes Dosil is a senior research scientist at the Centro de Investigación del Cáncer (CSIC/University of Salamanca). After receiving a B.S. in biology at the University of Santiago de Compostela (Spain), she earned a Ph.D. from the same University. Her thesis focussed on cloning and gene expression of proteins isolated from thymic cells.

She went on to do a postdoc at Princeton University (U.S.A.) with Ihor Lemischka, working on the functional and biochemical characterization of kinases and phosphatases specific of hematopoietic stem cells. After this, she joined the laboratory of James Konopka at the State University of New York, Stony Brook (U.S.A) and worked (1997-2000) on the structural analysis of a G-protein coupled receptor in Saccharomyces cerevisiae. 

Mercedes Dosil was part of the research team of Xosé R. Bustelo at the Centro de Investigación del Cancer of Salamanca during 2000-2001. In 2002 she initiated her independent line of research, that is focussed on the functional characterization of proteins required for ribosome biogenesis, with a special interest on their integration with the rest of molecular processes needed for cell growth. Currently she is associate professor (Department of Biochemistry and Molecular Biology) of the University of Salamanca.

Mercedes Dosil Castro
Contact

Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n
37007 Salamanca
SPAIN

Areas of Research
  1. Dissection of the initial steps of ribosome formation in the nucleolus.
  2. Characterization of distinctive features of ribosome formation in human cells
  3. Diregulation of ribosome assembly in cancer
Projects

  • Ministerio de Ciencia, Innovación y Universidades (2018-2020)

    Ensamblaje y maduración de la subunidad pequeña de los ribosomas en eucariotas

  • Ministerio de Economía y Competitividad (2015-2017)

    Mecanismos moleculares que integran distintos pasos de la ruta de síntesis de ribosomas.

  • Fundación Samuel Solórzano Barruso (2014-2014)

    Caracterización funcional de factores de síntesis de ribosomas en células normales y tumorales

  • Ministerio de Ciencia e Innovación (2012-2014)

    Funciones moleculares de factores de biogénesis de ribosomas.

  • Fundación Samuel Solózano Barruso (2010-2010)

    Función y regulación de proteínas esenciales para la formaci´n de los ribosomas durante el cilo celular y en respuesta a cambio ambientales.

  • Ministerio de Ciencia e Innovación (2009-2011)

    CARACTERIZACION FUNCIONAL DE PROTEINAS ESENCIALES PARA LA FORMACION DE LOS RIBOSOMAS

  • Ministerio de Educación y Ciencia (2006-2008)

    FUNCION Y REGULACION DE PROTEINAS QUE INICIAN LA FORMACION DE LOS RIBOSOMAS

  • Ministerio de Ciencia y Tecnología (2002-2005)

    Función de la proteína PWP2 en citocinésis y regulación del citoesqueleto celular.

  • Junta de Castilla y León (2002-2004)

    Análisis genómico funcional y bioquímico de rutas de transducción de señales mediadas por la oncoproteina VAV en linfocitos T

Publications

(*) Means equal contribution as senior authors.



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  • Mercedes Dosil Castro Mercedes Dosil Castro

    Mercedes Dosil Castro

    Ribosome synthesis and cell growth

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    Biography

    Mercedes Dosil is a senior research scientist at the Centro de Investigación del Cáncer (CSIC/University of Salamanca). After receiving a B.S. in biology at the University of Santiago de Compostela (Spain), she earned a Ph.D. from the same University. Her thesis focussed on cloning and gene expression of proteins isolated from thymic cells.

    She went on to do a postdoc at Princeton University (U.S.A.) with Ihor Lemischka, working on the functional and biochemical characterization of kinases and phosphatases specific of hematopoietic stem cells. After this, she joined the laboratory of James Konopka at the State University of New York, Stony Brook (U.S.A) and worked (1997-2000) on the structural analysis of a G-protein coupled receptor in Saccharomyces cerevisiae. 

    Mercedes Dosil was part of the research team of Xosé R. Bustelo at the Centro de Investigación del Cancer of Salamanca during 2000-2001. In 2002 she initiated her independent line of research, that is focussed on the functional characterization of proteins required for ribosome biogenesis, with a special interest on their integration with the rest of molecular processes needed for cell growth. Currently she is associate professor (Department of Biochemistry and Molecular Biology) of the University of Salamanca.

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  • Xosé R. García Bustelo Xosé R. García Bustelo

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    ROLE OF ONCOGENIC MOLECULES AND CYTOSKELETAL REGULATORS IN CANCER AND OTHER HIGH-INCIDENCE DISEASES

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    Dr. Xosé R. Bustelo
    Profesor de Investigación (CSIC)
    Investigador Principal, CIC
    Director, Unidad de Genómica y Proteómica
    Coordinador Nacional, Programa de Genómica, Proteómica y Bioinformática (Red Temática de Investigación Cooperativa en Cáncer)
    Laboratorio 2

    923294802
    923294743
    xbustelo@usal.es

    Centro de Investigación del Cáncer
    Universidad de Salamanca-CSIC
    Campus Unamuno s/n
    E-37007 Salamanca
    España/Spain

    Biography

    Dr. Bustelo gained his Ph.D at the University of Santiago (Santiago de Compostela, Galicia, Spain) in 1990.


    His scientific training outside Spain includes three years (1990-1993) as a postdoctoral fellow at the Bristol Myers Squibb Pharmaceutical Research Institute (Princeton, New Jersey, USA), three years (1993-1996) as a Research Scientist at the same Institution, and four years (1996-1999) as Assistant Professor at the Department of Pathology at the State University of New York (Stony Brook, New York, USA.).


    Since his return to Spain (2002), he has been working in the Spanish National Research Council (CSIC) as Tenured Scientist (2000-2004), Staff Scientist (2004-2005), and Full Professor (2005-Present).


    His research line focuses on the functional characterization of molecules involved in signal transduction that have oncogenic capacity, with special emphasis on oncoproteins that connect the stimulation of membrane receptors with signalling routes involved in cytoskeletal and mitogenic changes.


    His work in this field has been awarded with several national and international scientific awards, including the Catacosinos Young Investigator Award for Cancer Research (1996), the Baldwin Award for Breast Cancer Research (1997), the Sinsheimer Award for Cancer Research (1997) and, more recently, the Echevarne National Oncology Award (2003), the Golden Medal of the Padrón Brotherhood (2006), the Fundación Mutua Madrileña Award (2007), the Pfizer Research Award (2007), and the "Severo Ochoa" Award for Biomedical Research (2007).


    His research group has been recognized in 2007 by the Castilla-León Autonomous Government as "Castilla-León Research Group of Excellence".

     

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