CENTRO DE INVESTIGACION DEL CANCER

  • Laboratorio 3

Mercedes Dosil Castro

Ribosome synthesis and cell growth

Biography

Mercedes Dosil is a senior research scientist at the Centro de Investigación del Cáncer (CSIC/University of Salamanca). After receiving a B.S. in biology at the University of Santiago de Compostela (Spain), she earned a Ph.D. from the same University. Her thesis focussed on cloning and gene expression of proteins isolated from thymic cells.

She went on to do a postdoc at Princeton University (U.S.A.) with Ihor Lemischka, working on the functional and biochemical characterization of kinases and phosphatases specific of hematopoietic stem cells. After this, she joined the laboratory of James Konopka at the State University of New York, Stony Brook (U.S.A) and worked (1997-2000) on the structural analysis of a G-protein coupled receptor in Saccharomyces cerevisiae. 

Mercedes Dosil was part of the research team of Xosé R. Bustelo at the Centro de Investigación del Cancer of Salamanca during 2000-2001. In 2002 she initiated her independent line of research, that is focussed on the functional characterization of proteins required for ribosome biogenesis, with a special interest on their integration with the rest of molecular processes needed for cell growth. Currently she is associate professor (Department of Biochemistry and Molecular Biology) of the University of Salamanca.

Mercedes Dosil Castro
Contact

Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n
37007 Salamanca
SPAIN

Areas of Research
  1. Dissection of the initial steps of ribosome formation in the nucleolus.
  2. Characterization of distinctive features of ribosome formation in human cells
  3. Diregulation of ribosome assembly in cancer
Projects

  • Ministerio de Ciencia, Innovación y Universidades (2018-2020)

    Ensamblaje y maduración de la subunidad pequeña de los ribosomas en eucariotas

  • Ministerio de Economía y Competitividad (2015-2017)

    Mecanismos moleculares que integran distintos pasos de la ruta de síntesis de ribosomas.

  • Fundación Samuel Solórzano Barruso (2014-2014)

    Caracterización funcional de factores de síntesis de ribosomas en células normales y tumorales

  • Ministerio de Ciencia e Innovación (2012-2014)

    Funciones moleculares de factores de biogénesis de ribosomas.

  • Fundación Samuel Solózano Barruso (2010-2010)

    Función y regulación de proteínas esenciales para la formaci´n de los ribosomas durante el cilo celular y en respuesta a cambio ambientales.

  • Ministerio de Ciencia e Innovación (2009-2011)

    CARACTERIZACION FUNCIONAL DE PROTEINAS ESENCIALES PARA LA FORMACION DE LOS RIBOSOMAS

  • Ministerio de Educación y Ciencia (2006-2008)

    FUNCION Y REGULACION DE PROTEINAS QUE INICIAN LA FORMACION DE LOS RIBOSOMAS

  • Ministerio de Ciencia y Tecnología (2002-2005)

    Función de la proteína PWP2 en citocinésis y regulación del citoesqueleto celular.

  • Junta de Castilla y León (2002-2004)

    Análisis genómico funcional y bioquímico de rutas de transducción de señales mediadas por la oncoproteina VAV en linfocitos T

Publications

(*) Means equal contribution as senior authors.



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Patents
Group
  • Mercedes Dosil Castro Mercedes Dosil Castro

    Mercedes Dosil Castro

    Ribosome synthesis and cell growth

    Telf.:

    Fax:

    Email: mdosil@usal.es

    Contact
    Biography

    Mercedes Dosil is a senior research scientist at the Centro de Investigación del Cáncer (CSIC/University of Salamanca). After receiving a B.S. in biology at the University of Santiago de Compostela (Spain), she earned a Ph.D. from the same University. Her thesis focussed on cloning and gene expression of proteins isolated from thymic cells.

    She went on to do a postdoc at Princeton University (U.S.A.) with Ihor Lemischka, working on the functional and biochemical characterization of kinases and phosphatases specific of hematopoietic stem cells. After this, she joined the laboratory of James Konopka at the State University of New York, Stony Brook (U.S.A) and worked (1997-2000) on the structural analysis of a G-protein coupled receptor in Saccharomyces cerevisiae. 

    Mercedes Dosil was part of the research team of Xosé R. Bustelo at the Centro de Investigación del Cancer of Salamanca during 2000-2001. In 2002 she initiated her independent line of research, that is focussed on the functional characterization of proteins required for ribosome biogenesis, with a special interest on their integration with the rest of molecular processes needed for cell growth. Currently she is associate professor (Department of Biochemistry and Molecular Biology) of the University of Salamanca.

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  • Blanca Nieto Bernáldez Blanca Nieto Bernáldez

    Blanca Nieto Bernáldez

    Telf.:

    Fax:

    Email: blancanietob@gmail.com

    Contact
    Biography
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Formers Members
  • Mª del Pilar Martín Marcos Mª del Pilar Martín Marcos

    Mª del Pilar Martín Marcos

    Telf.:

    Fax:

    Email: a21141@usal.es

    Contact
    Biography
    She worked in the group of Mercedes Dosil in 2007 and 2008. She is currently a postdoctoral fellow in the laboratory of Alan Hinnebusch (NIH, U.S.A.) ×
  • Giulia Moriggi Giulia Moriggi

    Giulia Moriggi

    Telf.:

    Fax:

    Email: giuliabio@yahoo.it

    Contact
    Biography

    Degrees in Biology (2006) and Molecular Biology (2008) from University of La Sapienza (Rome, Italy). Predoctoral student (BSCH/USAL) since November 2010 in the laboratory of Mercedes Dosil.

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  • Jorge Pérez Fernández Jorge Pérez Fernández

    Jorge Pérez Fernández

    Telf.:

    Fax:

    Email: jpfernandez@usal.es

    Contact
    Biography

    He was in the group of Mercedes Dosil from 2004 to 2007. He is a currently a postdoctoral fellow in the group of H. Tschochner (Regensburg University, Germany)

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